Amino-acetonitrile derivatives (AADs or ‘orange’)

What do they treat?


How can they be administered?

A variety of application methods for administering pesticide products to cattle are in use.


  • Always check label information as dose rates for cattle are often higher than those for sheep.


Monepantel resistance not reported from cattle roundworms, however, resistance has been reported from Australia in the closely related sheep barber’s pole worm (Haemonchus contortus).

A variety of application methods for administering pesticide products to cattle are in use.


  • Generally AADs have a wide margin of safety to mammals.

Everyone working in the rural industry has a ‘duty of care’; a legal obligation to provide a safe workplace for everyone on the property.


  • Always check the product label before use for specific withholding periods (WHP) and export slaughter interval (ESI) periods. Current ESI periods can be confirmed on the APVMA website.

Withholding periods are mandatory with all registered veterinary products used to treat animals for internal and external parasites.

Types of amino-acetonitrile derivative

A guide to the different actives and the pests they affect are in Table 1. See the Products Search Guides for WormBoss, TickBoss, LiceBoss and FlyBoss for the appropriate formulation and application method for your target pest. Note combinations and mixtures of actives may improve treatment efficacy.

Table 1. Amino-acetonitrile derivative, their active, combinations and mixtures and a summary of the targeted parasites for which formulations are registered for. Boxed check marks indicate the pest targeted by multiple actives.


Pests targeted (may vary with formulation)







Intestinal tapeworm

Liver fluke





Combination (all actives target boxed parasite)


Abamectin and monepantel


What are they?

Amino-acetonitrile derivatives (AADs) are a new class of synthetic anthelmintics with broad-spectrum activity against roundworms that are resistant to the benzimidazoles, imidazothiazoles and macrocyclic lactones.

How do they work?

The mode of action of AADs is to cause paralysis by binding to a receptor that has only been found in roundworms.