Salicylanilides (SC)

What do they treat?

 Liver fluke

  • Oxyclozanide is currently only available in Australia as a mixture with levamisole

Note:  Toxic to many aquatic organisms.

How can they be administered?

A variety of application methods for administering pesticide products to cattle are in use.


  • Always check label information as dose rates for cattle are often higher than those for sheep.


Reported in:  Liver fluke

What is resistance?


  • Salicylanilides are generally regarded as compounds of low-toxicity but can cause eye and skin irritation in some people.

Everyone working in the rural industry has a ‘duty of care’; a legal obligation to provide a safe workplace for everyone on the property.


  • Always check the product label before use for specific withholding periods (WHP) and export slaughter interval (ESI) periods. Current ESI periods can be confirmed on the APVMA website.

Withholding periods are mandatory with all registered veterinary products used to treat animals for internal and external parasites.

Types of salicylanilide

A guide to the active and the pests it affects is in Table 1. See the Products Search Guides for WormBoss, TickBoss, LiceBoss and FlyBoss for the appropriate formulation and application method for your target pest. Note combinations and mixtures of actives may improve treatment efficacy.

Table 1. Salicylanilide, their active, combinations and mixtures and a summary of the targeted parasites for which formulations are registered for. Boxed check marks indicate the pest targeted by multiple actives.


Pests targeted (may vary with formulation)







Tape worm

Liver fluke






Mixtures (multiple targets)


Oxyclozanide and levamisole



What are they?

Salicylanilides are narrow-spectrum anthelmintics.

They were first introduced in the 1960s and 70s.

How do they work?

Salicylanilides disrupt the energy producing mitochondria within the parasites cells impairing mobility.